Molecular Assembly Lines in Active Droplets

Tyler S. Harmon; Frank Jülicher

doi:10.1103/physrevlett.128.108102

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arXiv · 2103.09886

Molecular Assembly Lines in Active Droplets

Tyler S. Harmon·Frank Jülicher

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Abstract

Large protein complexes are assembled from protein subunits to form a specific structure. In our theoretic work, we propose that assembly into the correct structure could be reliably achieved through an assembly line with a specific sequence of assembly steps. Using droplet interfaces to position compartment boundaries, we show that an assembly line can be self organized by active droplets. As a consequence, assembly steps can be arranged spatially so that a specific order of assembly is achieved and incorrect assembly is strongly suppressed.

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Tyler S. Harmon, Frank Jülicher. 2021-03-17. Molecular Assembly Lines in Active Droplets. https://doi.org/10.1103/physrevlett.128.108102

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