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arXiv · 2106.12297

Network analytics for drug repurposing in COVID-19

Nicoleta Siminea·Victor Popescu·Jose Angel Sanchez Martin·Daniela Florea·Georgiana Gavril·Ana-Maria Gheorghe·Corina Itcus·Krishna Kanhaiya·Octavian Pacioglu·Laura Ioana Popa·Romica Trandafir·Maria Iris Tusa·Manuela Sidoroff·Mihaela Paun·Eugen Czeizler·Andrei Paun·Ion Petre
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Abstract

To better understand the potential of drug repurposing in COVID-19, we analyzed control strategies over essential host factors for SARS-CoV-2 infection. We constructed comprehensive directed protein-protein interaction networks integrating the top ranked host factors, drug target proteins, and directed protein-protein interaction data. We analyzed the networks to identify drug targets and combinations thereof that offer efficient control over the host factors. We validated our findings against clinical studies data and bioinformatics studies. Our method offers a new insight into the molecular details of the disease and into potentially new therapy targets for it. Our approach for drug repurposing is significant beyond COVID-19 and may be applied also to other diseases.

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Nicoleta Siminea, Victor Popescu, Jose Angel Sanchez Martin, Daniela Florea, Georgiana Gavril, Ana-Maria Gheorghe, Corina Itcus, Krishna Kanhaiya, Octavian Pacioglu, Laura Ioana Popa, Romica Trandafir, Maria Iris Tusa, Manuela Sidoroff, Mihaela Paun, Eugen Czeizler, Andrei Paun, Ion Petre. 2021-06-23. Network analytics for drug repurposing in COVID-19. https://arxiv.org/abs/2106.12297

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