Periodontitis and preeclampsia in pregnancy: A systematic review and meta-analysis

Quynh-Anh Le; Rahena Akhter; Kimberly M. Coulton; Ngoc T. N Vo; Le T. Y Duong; Hoang V. Nong; Albert Yaacoub; George Condous; Joerg Eberhard; Ralph Nanan

arXiv · 2108.05186

Periodontitis and preeclampsia in pregnancy: A systematic review and meta-analysis

Quynh-Anh Le·Rahena Akhter·Kimberly M. Coulton·Ngoc T. N Vo·Le T. Y Duong·Hoang V. Nong·Albert Yaacoub·George Condous·Joerg Eberhard·Ralph Nanan

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Abstract

Objectives: A conflicting body of evidence suggests localized periodontal inflammation to spread systemically during pregnancy inducing adverse pregnancy outcomes. This systematic review and meta-analysis aimed to specifically evaluate the relationship between periodontitis and preeclampsia. Methods: Electronic searches were carried out in Medline, Pubmed, Cochrane Controlled Clinical Trial Register to identify and select observational case-control and cohort studies that analyzed the association between periodontal disease and preeclampsia. Prisma guidelines and Moose checklist were followed. Results: Thirty studies including six cohorts and twenty-four case-control studies were selected. Periodontitis was significantly associated with increased risk for preeclampsia, especially in a subgroup analysis including cohort studies and subgroup analysis with lower-middle-income countries. Conclusion: Periodontitis appears as a significant risk factor for preeclampsia, which might be even more pronounced in lower-middle-income countries.

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Quynh-Anh Le, Rahena Akhter, Kimberly M. Coulton, Ngoc T. N Vo, Le T. Y Duong, Hoang V. Nong, Albert Yaacoub, George Condous, Joerg Eberhard, Ralph Nanan. 2021-08-09. Periodontitis and preeclampsia in pregnancy: A systematic review and meta-analysis. https://arxiv.org/abs/2108.05186

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