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arXiv · 2109.14667

On the quasi-steady-state assumption in enzyme kinetics: rigorous analysis

Vasiliki Bitsouni·Nikolaos Gialelis·Ioannis G. Stratis
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Abstract

We study, from a purely quantitative point of view, the quasi-steady-state assumption for the fundamental mathematical model of the general enzymatic reaction: we re-establish, on a rigorous basis, certain already known results and we propose a novel approach to the subject, that makes waivable an ambiguous, widely used, practice. In particular, we define the two parts of the assumption in a quantitative fashion, we employ a simple algorithm for the proper scaling of the corresponding problem which naturally provides us with the necessary and sufficient information, and we comment, among other issues, on a dispensable third part of the assumption.

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Vasiliki Bitsouni, Nikolaos Gialelis, Ioannis G. Stratis. 2021-09-29. On the quasi-steady-state assumption in enzyme kinetics: rigorous analysis. https://arxiv.org/abs/2109.14667

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