Individual- and pair-based models of epidemic spreading: master equations and analysis of their forecasting capabilities

Abstract

Mathematical modeling of disease spreading plays a crucial role in understanding, controlling and preventing epidemic outbreaks. In a microscopic description of the propagation of a disease over the complex network of human contacts, the probability that an individual is in a given state (susceptible, infectious, recovered etc) depends on the state of its neighbors in the network. Thus it depends on the state of pairs of nodes, which in turns depends on triples, in a hierarchy of dynamical dependencies. In order to produce models that are at the same time reliable and manageable, one has to understand how to truncate such a hierarchy, and how the chosen order of approximation affects the ability of the model to forecast the real temporal evolution of an epidemics. In this paper we provide a systematic analysis of the reliability (under different hypotheses on the quantity and quality of available data) of the predictions obtained by truncating the hierarchy either at the level of individuals or at the level of pairs. We find that pair-based models are reliable tools both for estimating the epidemiological parameters and for forecasting the temporal evolution of the epidemics, under all conditions taken into account in our work. However, a pair-based approach provides a much better prediction of an individual-based one, only if better data, namely information on the state of node pairs, are available. Overall, our results suggest that more refined mathematical models need to be informed by improved contact tracing techniques to better support decision on policies and containment measures to adopt.