DNA Mutations via Chern-Simons Currents

Francesco Bajardi; Lucia Altucci; Rosaria Benedetti; Salvatore Capozziello; Maria Rosaria Del Sorbo; Gianluigi Franci; Carlo Altucci

doi:10.1140/epjp/s13360-021-01960-5

arXiv · 2110.05934

DNA Mutations via Chern-Simons Currents

Francesco Bajardi·Lucia Altucci·Rosaria Benedetti·Salvatore Capozziello·Maria Rosaria Del Sorbo·Gianluigi Franci·Carlo Altucci

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Abstract

We test the validity of a possible schematization of DNA structure and dynamics based on the Chern-Simons theory, that is a topological field theory mostly considered in the context of effective gravity theories. By means of the expectation value of the Wilson Loop, derived from this analogue gravity approach, we find the point-like curvature of genomic strings in KRAS human gene and COVID-19 sequences, correlating this curvature with the genetic mutations. The point-like curvature profile, obtained by means of the Chern-Simons currents, can be used to infer the position of the given mutations within the genetic string. Generally, mutations take place in the highest Chern-Simons current gradient locations and subsequent mutated sequences appear to have a smoother curvature than the initial ones, in agreement with a free energy minimization argument.

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Francesco Bajardi, Lucia Altucci, Rosaria Benedetti, Salvatore Capozziello, Maria Rosaria Del Sorbo, Gianluigi Franci, Carlo Altucci. 2021-10-07. DNA Mutations via Chern-Simons Currents. https://doi.org/10.1140/epjp/s13360-021-01960-5

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