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arXiv · 2110.10134

Broadband-excitation-based mechanical spectroscopy of highly viscous tissue-mimicking phantoms

Magdalena A. Urbańska·Sylwia M. Kolenderska·Sophia A. Rodrigues·Sachin S. Thakur·Frédérique Vanholsbeeck
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Abstract

Standard rheometers assess mechanical properties of viscoelastic samples up to 100~Hz, which often hinders the assessment of the local-scale dynamics. We demonstrate that high-frequency analysis can be achieved by inducing broadband Rayleigh waves and monitoring their media-dependent propagation using Optical Coherence Tomography. Here, we present a new broadband wave analysis based on two-dimensional Fourier Transformation. We validated this method by comparing the mechanical parameters to monochromatic excitation data and a standard oscillatory test. Our method allows for high-frequency mechanical spectroscopy, which could be used to investigate the local-scale dynamics of different biological tissues and the influence of diseases on their microstructure.

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Magdalena A. Urbańska, Sylwia M. Kolenderska, Sophia A. Rodrigues, Sachin S. Thakur, Frédérique Vanholsbeeck. 2021-10-15. Broadband-excitation-based mechanical spectroscopy of highly viscous tissue-mimicking phantoms. https://doi.org/10.1364/oe.445259

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