SearcharxivSearch

arXiv · 2112.05951

Applying a System Dynamics Approach for the Pharmaceutical Industry: Simulation and Optimization of the Quality Control Process

Abstract

As countries interact more and more, technology gains a decisive role in facilitating today's increased need for interconnection. At the same time, systems, becoming more advanced as technology progresses, feed each other and can produce highly complex and unpredictable results. However, with this ever-increasing need for interconnected operations, complex problems arise that need to be effectively tackled. This need extends far beyond the scientific and mechanical fields, covering every aspect of life. Systemic Thinking Philosophy and the System Dynamics methodology now seem to be more relevant than ever and their practical implementation in real-life industrial cases has started to become a trend. Companies that decide to implement such approaches can achieve significant improvements to the effectiveness of their operations and gain a competitive advantage. This research, influenced by the Systemic Thinking Philosophy, applies a System Dynamics approach in practice by improving the quality control process of a pharmaceutical company. The process is modeled, simulated, analyzed, and improvements are performed to achieve more effective and efficient operations. The results show that all these steps led to a successful identification and optimization of the critical factors, and a significant process improvement was achieved.

Explore related subjects

Keep this discovery

BibTeXRIS

Evripidis P. Kechagias, Dimitrios M. Miloulis, Georgios Chatzistelios, Sotiris P. Gayialis, Georgios A. Papadopoulos. 2021-12-11. Applying a System Dynamics Approach for the Pharmaceutical Industry: Simulation and Optimization of the Quality Control Process. https://doi.org/10.37394/232015.2021.17.91

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related papers

Structured Stochastic Representations of Integrated Dynamic Strategies

Dynamic allocation decisions couple present resource use to evolving internal conditions, delayed returns, and future costs. We represent this interaction by four probability localizations linked through regime-indexed, graph-constrained column-stochastic operators. Pre-action state or context selects a locally affine model, while action-dependent changes update subsequent regimes, yielding a causal switched representation of nonlinear evolution. We characterize operator identifiability relative to the graph, the stochastic constraints, and the sampled embedding, separating coefficient recovery from predictive equivalence on the decision domain. Decision making is then formulated through implementable return--cost acceptability regions. Finite-horizon error propagation supplies conservative classification margins, and simultaneous intervals distinguish model-relative near-optimality from certified $\epsilon$-optimality over a declared finite policy class. Regime-indexed stochastic feedback is admitted when it satisfies the same certification test. Reproducible synthetic laboratories for personal preparation, supplier participation, and customer retention illustrate exact, operator-supplied, and noisy feedback cases. Multinomial experiments show improving recovery of the feedback function and fewer unresolved decisions with increasing sample size, while unrestricted off-policy recovery remains limited. The contribution is a structure-preserving representation--identification--decision workflow, not a domain-specific physiological or commercial calibration.

eess.SY

Fusion Estimation in Multi-sensor Systems for Data Packets with Disrupted Identities

In this paper, we explore the problem of fusion estimation for a multi-sensor system where the identity of the data packet received by each sensor may be disrupted or incorrect due to confusion in device identity allocation, communication protocol defects, or the lack of a clear sensor identifier. This can result in a random shuffle of the data components during the fusion estimation process, compromising the performance of the fusion estimation. To address this issue, we introduce the concepts of permutations and symmetry groups to describe this phenomenon as data packet permutation. We construct statistics to simplify the information set, developing two algorithms: a Bayesian approach, which performs fusion using posterior arrangement probabilities, and a greedy approach, which effectively improves estimation performance by guessing the likely data arrangement. We compare these two algorithms and demonstrate that both are expectation error-bounded. We improve algorithms for information-scarce scenarios. By employing the expectation-maximization algorithm, we fill in the prior information of data arrangement where the correct convergence is proven. Finally, we present numerical simulations to validate our results.

eess.SY

Quantifying the Reality Gap for RL-Based UAV Placement at mmWave and Sub-THz

Reinforcement learning (RL) policies for unmanned aerial vehicle (UAV) placement in mmWave and sub-terahertz networks are typically trained on simplified analytical channels. We quantify the resulting sim-to-real gap on a real urban map of Doha, Qatar, at carriers {28, 140, 183, 300} GHz and altitudes {50, 75, 100, 125} m, evaluating three channel pipelines: an analytical model (FSPL + atmospheric absorption + cuboid LoS), full Monte-Carlo ray tracing in Sionna RT with ITU-R P.676-13 absorption, and a deterministic-LoS hybrid that reuses Sionna's mesh under a closed-form path-gain expression. We formalize the gap on the spatial SNR distribution via four metrics, namely bias, RMSE, Jensen-Shannon divergence, and optimum-deployment displacement. Three findings emerge: at 28/140 GHz, $\sim$70% of the apparent -5.6/-4.8 dB Sionna bias is Monte-Carlo undersampling and shrinks to -1.7/-1.5 dB after mitigation; at 183 GHz a -9.2 dB residual isolates the atmospheric absorption / ITU-R P.676 line-shape disagreement; at 300 GHz the stochastic ray tracer agrees with the analytical model only coincidentally, with a +3.8 dB structural offset exposed by the deterministic-LoS pipeline. Across all carriers the linear-domain regret of the analytical-trained policy stays $\geq$ 0.93, indicating practical near-optimality but with a carrier-resolved SNR bias that warrants explicit reporting.

eess.SY