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arXiv · 2202.09847

Evolution and Mutations of Beta 2 Microglobulin

J. C. Phillips
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Abstract

Here we examine the evolution of beta-2 microglobulin in terms of its hydropathic shapes, a theoretical construct that has revealed important trends. The dynamics of many proteins are largely driven by interactions between the protein itself and the thin water film that covers it. \b{eta}2m constitutes the basic building unit of the immunoglobulin superfamily; the evolution of its amino acid sequences from chickens to mice to humans provides new information about its multiple functions. Our hydrodynamic method involves concepts of topological shape evolution towards a critical point for optimized functions. The results are in excellent agreement with experiment for the details of the mouse-human evolution, as well as both the dangerous natural amyloid aggregation mutation D76N, and six other DN test mutations.

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J. C. Phillips. 2022-02-20. Evolution and Mutations of Beta 2 Microglobulin. https://arxiv.org/abs/2202.09847

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