Searcharxiv⌕ Search
Home/Archive/arXiv

arXiv · 2203.11015

Filter Drug-induced Liver Injury Literature with Natural Language Processing and Ensemble Learning

Xianghao Zhan·Fanjin Wang·Olivier Gevaert
View original source ↗Read source document ↗Export metadata ↓

Abstract

Drug-induced liver injury (DILI) describes the adverse effects of drugs that damage liver. Life-threatening results including liver failure or death were also reported in severe DILI cases. Therefore, DILI-related events are strictly monitored for all approved drugs and the liver toxicity became important assessments for new drug candidates. These DILI-related reports are documented in hospital records, in clinical trial results, and also in research papers that contain preliminary in vitro and in vivo experiments. Conventionally, data extraction from previous publications relies heavily on resource-demanding manual labelling, which considerably decreased the efficiency of the information extraction process. The recent development of artificial intelligence, particularly, the rise of natural language processing (NLP) techniques, enabled the automatic processing of biomedical texts. In this study, based on around 28,000 papers (titles and abstracts) provided by the Critical Assessment of Massive Data Analysis (CAMDA) challenge, we benchmarked model performances on filtering out DILI literature. Among four word vectorization techniques, the model using term frequency-inverse document frequency (TF-IDF) and logistic regression outperformed others with an accuracy of 0.957 with our in-house test set. Furthermore, an ensemble model with similar overall performances was implemented and was fine-tuned to lower the false-negative cases to avoid neglecting potential DILI reports. The ensemble model achieved a high accuracy of 0.954 and an F1 score of 0.955 in the hold-out validation data provided by the CAMDA committee. Moreover, important words in positive/negative predictions were identified via model interpretation. Overall, the ensemble model reached satisfactory classification results, which can be further used by researchers to rapidly filter DILI-related literature.

Explore related subjects

cs.IRcs.LGstat.AP

Keep this discovery

BibTeXRIS

Xianghao Zhan, Fanjin Wang, Olivier Gevaert. 2022-03-09. Filter Drug-induced Liver Injury Literature with Natural Language Processing and Ensemble Learning. https://doi.org/10.1109/jbhi.2022.3193365

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related papers

arXiv2026

UniRec: Cross-stage Multi-Task Fusion with Preference Alignment for Cascaded Recommender Systems

Industrial recommender systems use cascaded stages with different objectives, feature spaces, and latency constraints. Optimizing pre-ranking and ranking separately can create cross-stage inconsistency: upstream models may filter out items preferred by downstream rankers, and independently tuned downstream fusion can offset upstream improvements. Existing multi-task fusion methods focus on multi-objective fusion within the ranking stage, and cross-stage methods typically only add a downstream score factor to upstream ranking. Joint optimization of fusion modules across both stages remains largely unexplored. We propose UniRec, a Unified Cross-stage Recommendation Fusion model. First, the two fusion agents partially share input embeddings and are trained in a single computation graph, so gradients from either stage propagate through the shared representation and influence the other. Second, we introduce a dual-axis preference alignment objective: a vertical cross-stage consistency term transfers downstream pairwise preferences to the upstream fusion score, and a horizontal compact aggregation term reorganizes dozens of pairwise objectives over heterogeneous prior signals into bidirectional preference evidence. Third, we find that unconstrained end-to-end fusion optimization can exploit imbalances in item attribute distributions, over-concentrating on high-reward regions at the cost of other objectives. We therefore add an attribute group-relative regularization that computes advantages within attribute groups and normalizes the policy over the same groups, so uniformly promoting an entire high-reward group yields no optimization gain. Offline, UniRec consistently outperforms single-stage fusion and cross-stage coordination baselines. Online A/B tests show a 0.616\% gain in app usage duration. UniRec is fully deployed on the Kuaishou platform.

cs.IR↗
arXiv2026

VikingRAG: Accurate and Token-efficient Retrieval-augmented Generation over Structured Documents

State-of-the-art retrieval-augmented generation (RAG) methods exploit document structures to acquire sufficient evidence, but often incur substantial token costs. To reduce structural-context tokens without compromising high RAG accuracy, we present {\sf VikingRAG}, a directory-aware semantic data management system that tightly integrates semantic and structural access to support structural-context-efficient, evidence-gap-driven multi-round retrieval. To further reduce token overhead of multi-round interaction, we materialize agentic multi-round retrieval traces as experience edges, and reuse these edges for similar queries, avoiding repeated multi-round exploration. To additionally reduce token costs when agentic multi-round retrieval is unnecessary, we introduce an adaptive escalation strategy that answers from one-round experience-augmented retrieval when the evidence is sufficient, and invokes agentic multi-round retrieval only otherwise. Experiments on real datasets show that the base system {\sf VikingRAG} matches high accuracy of state-of-the-art methods while consuming only 11.6\%--51.9\% of their tokens. With retrieval-trace reuse and adaptive escalation, token costs drop to 5.1\%--32.5\% while maintaining competitive accuracy and practical document-storage performance, showing the utility of this work for emerging AI knowledge bases.

cs.IR↗
arXiv2026

TimelyRAG: Semantic-Temporal Hybrid Retrieval for Time-Critical Question Answering in Overlapping-Evolving Documents

Although large language models (LLMs) and retrieval-augmented generation (RAG) have advanced open-domain question answering (QA), they remain unreliable when documents evolve through amendments. Existing time-sensitive retrieval methods address only the disjoint-evolving environment, where each update is an independent snapshot. However, laws, policies, and regulations often operate in overlapping-evolving environments, where amendments override earlier clauses while preserving most content, creating strong semantic overlap across versions. We propose TimelyRAG, a retriever-agnostic framework that incorporates temporal distance into ranking to align queries with version-appropriate documents. We also introduce TimelyQABench, the first benchmark for regulation-heavy domains with overlapping-evolving challenges. Experiments show consistent gains, up to +28.6% in nDCG@10, highlighting the importance of temporal reasoning for reliable QA over evolving documents. All resources are available at https://github.com/kaist-dmlab/TimelyRAG.

cs.IR↗