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arXiv · 2204.06922

Calibration of scanning acoustic microscopy for the differentiation between unstable and stable atherosclerotic plaques by X-ray fluorescence imaging

Peter Modregger·Mallika Khosla·Prerana Chakrabarti·Özgül Öztürk·Kathryn M. Spiers·Mehmet Burcin Unlu·Bükem Tanören

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Abstract

Although cardiovascular diseases are the leading cause of death globally, non-invasive and inexpensive diagnostic tools for the identification of associated unstable atherosclerotic plaques are not yet available. Scanning acoustic microscopy offers a high potential to fill this critical gap in patient care. However, convincing validation and calibration of this technique requires high resolution maps of Ca concentrations of atherosclerotic plaques. Here, we demonstrate that synchrotron radiation-based X-ray fluorescence imaging with micrometer spatial resolution can provide such a gold standard.

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Peter Modregger, Mallika Khosla, Prerana Chakrabarti, Özgül Öztürk, Kathryn M. Spiers, Mehmet Burcin Unlu, Bükem Tanören. 2022-04-14. Calibration of scanning acoustic microscopy for the differentiation between unstable and stable atherosclerotic plaques by X-ray fluorescence imaging. https://arxiv.org/abs/2204.06922

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