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arXiv · 2204.09673

Guidelines for reporting cell types: the MIRACL standard

Tiago Lubiana·Paola Roncaglia·Christopher J. Mungall·Ellen M. Quardokus·Joshua D. Fortriede·David Osumi-Sutherland·Alexander D. Diehl
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Abstract

Cell types are at the root of modern biology, and describing them is a core task of the Human Cell Atlas project. Surprisingly, there are no standards for reporting new cell types, leading to a gap between classes mentioned in biomedical literature and the Cell Ontology, the primary registry of cell types. Here we introduce the Minimal Information Reporting About a CelL (MIRACL) standard, a guideline for describing cell types alongside scientific articles. In a MIRACL sheet, authors organize a label, a diagnostic description, a taxon, an anatomical structure, and a parent cell class for each cell type of interest. The MIRACL standard bridges the gap between wet-lab researchers and ontologists, facilitating the integration of biomedical knowledge into ontologies and artificial intelligence systems.

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Tiago Lubiana, Paola Roncaglia, Christopher J. Mungall, Ellen M. Quardokus, Joshua D. Fortriede, David Osumi-Sutherland, Alexander D. Diehl. 2022-04-18. Guidelines for reporting cell types: the MIRACL standard. https://arxiv.org/abs/2204.09673

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