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arXiv · 2206.04934

Response to: Significance and stability of deep learning-based identification of subtypes within major psychiatric disorders. Molecular Psychiatry (2022)

Xizhe Zhang·Fei Wang·Weixiong Zhang
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Abstract

Recently, Winter and Hahn [1] commented on our work on identifying subtypes of major psychiatry disorders (MPDs) based on neurobiological features using machine learning [2]. They questioned the generalizability of our methods and the statistical significance, stability, and overfitting of the results, and proposed a pipeline for disease subtyping. We appreciate their earnest consideration of our work, however, we need to point out their misconceptions of basic machine-learning concepts and delineate some key issues involved.

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Xizhe Zhang, Fei Wang, Weixiong Zhang. 2022-06-10. Response to: Significance and stability of deep learning-based identification of subtypes within major psychiatric disorders. Molecular Psychiatry (2022). https://doi.org/10.1038/s41380-022-01613-8

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