Tension-clock control of human mitotic chromosome oscillations

Nigel J. Burroughs; Andrew D. McAinsh

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arXiv · 2207.00481

Tension-clock control of human mitotic chromosome oscillations

Nigel J. Burroughs·Andrew D. McAinsh

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Abstract

During cell division paired (sister) chromosomes are observed to perform approximate saw-tooth oscillations across the cell mid-plane. Experimental data suggests that these oscillations are regulated through intersister tension. We propose a time dependent tension threshold model that exhibits three stable periodic solutions and the phase diagram can be generated semi-analytically. Incorporation of diffusive noise reproduces realistic oscillations, with realistic periods, amplitudes and reproducing the observation that either sister of the pair can switch direction first.

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Nigel J. Burroughs, Andrew D. McAinsh. 2022-07-01. Tension-clock control of human mitotic chromosome oscillations. https://arxiv.org/abs/2207.00481

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