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arXiv · 2207.03222

COVID-19 adaptive humoral immunity models: weakly neutralizing versus antibody-disease enhancement scenarios

Antoine Danchin·Oriane Pagani-Azizi·Gabriel Turinici·Ghozlane Yahiaoui
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Abstract

The interplay between the virus, infected cells and the immune responses to SARS-CoV-2 is still under debate. Extending the basic model of viral dynamics we propose here a formal approach to describe the neutralizing versus weakly (or non-)neutralizing scenarios and compare with the possible effects of antibody-dependent enhancement (ADE). The theoretical model is consistent with data available from the literature; we show that weakly neutralizing antibodies or ADE can both give rise to either final virus clearance or disease progression, but the immuno-dynamic is different in each case. Given that a significant part of the world population is already naturally immunized or vaccinated, we also discuss the implications on secondary infections infections following vaccination or in presence of immune system dysfunctions.

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Antoine Danchin, Oriane Pagani-Azizi, Gabriel Turinici, Ghozlane Yahiaoui. 2022-07-07. COVID-19 adaptive humoral immunity models: weakly neutralizing versus antibody-disease enhancement scenarios. https://arxiv.org/abs/2207.03222

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