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arXiv · 2207.07346

STRIKE-GOLDD 4.0: user-friendly, efficient analysis of structural identifiability and observability

Sandra Díaz-Seoane·Xabier Rey-Barreiro·Alejandro F. Villaverde
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Abstract

Structural identifiability and observability are desirable properties of systems biology models. Many software toolboxes have been developed for their analysis in the last decades. STRIKE-GOLDD is a generally applicable tool that can analyse non-linear, non-rational ODE models with unknown inputs. However, this generality comes at the expense of a lower computational efficiency than other tools. Here we present STRIKE-GOLDD 4.0, which includes a new algorithm, ProbObsTest, specifically designed for the analysis of rational models. ProbObsTest is significantly faster than the FISPO algorithm - which was already available in older versions of the toolbox - when applied to computationally expensive models. An important feature of both algorithms is their ability to analyse models with unknown inputs. Thus, their coexistence in the same toolbox provides a combination of general applicability and computational efficiency. STRIKE-GOLDD 4.0 is implemented as a free and open-source Matlab toolbox with a user-friendly graphical interface. It is available under a GPLv3 license and it can be downloaded from GitHub at https://github.com/afvillaverde/strike-goldd.

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Sandra Díaz-Seoane, Xabier Rey-Barreiro, Alejandro F. Villaverde. 2022-07-15. STRIKE-GOLDD 4.0: user-friendly, efficient analysis of structural identifiability and observability. https://arxiv.org/abs/2207.07346

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