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arXiv · 2208.03992

Perpetual Observational Studies: New strategies to support efficient implementation of observational studies and randomized trials in the infectious diseases arena

N. Hassoun-Kheir·C. H. van Werkhoven·J. Dunning·T. Jaenisch·J. van Beek·J. Bielicki·C. Butler·B. Francois·S. Harbarth·A. C. Hernandez Padilla·P. Horby·M. Koopmans·J. Lee·J. Rodriguez-Baño·E. Tacconelli·Y. Themistocleous·A. W. van der Velden·M. Bonten·H. Goossens·M. E. A. de Kraker
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Abstract

The increasing threat of emerging infectious diseases and antimicrobial resistance requires more efficient, high-quality research. Perpetual Observational Studies (POS) nested within a clinical research network can improve planning, quality and efficiency of interventional and observational studies, although real-life benefits and challenges need to be assessed. Ecraid (European Clinical Research Alliance on Infectious Diseases) has initiated POS and will monitor the impact for five specific infectious syndromes.

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N. Hassoun-Kheir, C. H. van Werkhoven, J. Dunning, T. Jaenisch, J. van Beek, J. Bielicki, C. Butler, B. Francois, S. Harbarth, A. C. Hernandez Padilla, P. Horby, M. Koopmans, J. Lee, J. Rodriguez-Baño, E. Tacconelli, Y. Themistocleous, A. W. van der Velden, M. Bonten, H. Goossens, M. E. A. de Kraker. 2022-08-08. Perpetual Observational Studies: New strategies to support efficient implementation of observational studies and randomized trials in the infectious diseases arena. https://doi.org/10.1016/j.cmi.2022.07.024

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