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arXiv · 2211.16294

Short and Long-range cyclic patterns in flows of DNA solutions in microfluidic obstacle arrays

Oskar E. Ström·Jason P. Beech·Jonas O. Tegenfeldt
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Abstract

We observe regular patterns emerging across multiple length scales with high-concentration DNA solutions in microfluidic pillar arrays at low Reynolds numbers and high Deborah. Interacting vortices between pillars lead to long-range order in the form of large travelling waves consisting of DNA at high concentration and extension. Waves are formed in quadratic arrays of pillars, while randomizing the position of the pillar in each unit cell of a quadratic array leads to suppression of the long-range patterns. We find that concentrations exceeding the overlap concentration of the DNA enables the waves, and exploring the behavior of the waves as a function of flow rate, buffer composition, concentration and molecular length, we identify elastic effects as central to the origin of the waves. Our work may not only help increase the low throughput that often limits sample processing in microfluidics, it may also provide a platform for further studies of the underlying viscoelastic mechanisms.

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Oskar E. Ström, Jason P. Beech, Jonas O. Tegenfeldt. 2022-11-29. Short and Long-range cyclic patterns in flows of DNA solutions in microfluidic obstacle arrays. https://arxiv.org/abs/2211.16294

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