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arXiv · 2212.08971

Development of a Novel Platform for in vitro Electrophysiological Recording

Giovanni Melle
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Abstract

This PhD thesis introduces the concept of meta-electrodes coupled with laser optoporation for high quality intracellular signals from hiPSCs-CM. These signals can be recorded on high-density commercial CMOS-MEAs from 3Brain characterized by thousands of electrode covered by a thin film of porous Platinum without any rework of the devices, 3D nanostructures or circuitry for electroporation. Subsequently, I attempted to translate these unique features of low invasiveness and reliability to other commercial MEA platforms, in order to develop a new tool for cardiac electrophysiological accurate recordings.

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Giovanni Melle. 2022-12-17. Development of a Novel Platform for in vitro Electrophysiological Recording. https://arxiv.org/abs/2212.08971

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