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arXiv · 2301.03516

Coherent Stokes Raman scattering microscopy (CSRS)

Sandro Heuke·Hervé Rigneault
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Abstract

We report the first implementation of laser scanning Coherent Stokes Raman scattering (CSRS - pronounced "sCiSsoRS") microscopy. To overcome the major challenge in CSRS imaging, we show how to suppress the fluorescence background by narrow bandpass filter and a lock-in based demodulation. Near background free CSRS imaging of polymer beads, human skin, onion cells, avocado flesh and the wing disc of a drosphila larva are presented. Finally, we explain and demonstrate numerically that CSRS solves a major obstacle of other coherent Raman techniques by sending a significant part (up to 100%) of the CSRS photons into the backward direction under tight focusing conditions. We believe that this discovery will pave the way for numerous technological advances, e.g. in epi-detected coherent Raman multi-focus imaging, real-time laser scanning based spectroscopy or efficient endoscopy.

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Sandro Heuke, Hervé Rigneault. 2023-01-09. Coherent Stokes Raman scattering microscopy (CSRS). https://doi.org/10.1038/s41467-023-38941-4

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