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arXiv · 2303.06988

Mechanical-scan-free and multi-color super-resolution imaging with diffractive spot array illumination

Ning Xu·Sarah E. Bohndiek·Zexing Li·Cilong Zhang·Qiaofeng Tan
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Abstract

Point-scanning microscopy approaches are transforming super-resolution imaging. Despite achieving parallel high-speed imaging using multifocal techniques, efficient multi-color capability with high-quality illumination is currently lacking. In this paper, we present for the first time Mechanical-scan-free and multi-Color Super-resolution Microscopy (MCoSM) by spot array illumination, which enables mechanical-scan-free super-resolution imaging with adjustable resolution and field of view (FoV) based on spatial light modulators (SLMs). Through 100s-10,000s super-resolution spot illumination with different FoV for imaging, we demonstrate the adjustable capacity of MCoSM. MCoSM extends current spectral imaging capabilities through a time-sharing process of different color illumination with phase-shifting scanning, while retaining the spatial flexibility of super-resolution imaging with diffractive spot array illumination. To showcase the prospects for further combining MCoSM with multi-color imaging, we also perform spectral unmixing (four-colors) on images of fluorescent beads at high resolution. MCoSM provides a versatile platform for studying molecular interactions in complex samples at the nanoscale level.

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Ning Xu, Sarah E. Bohndiek, Zexing Li, Cilong Zhang, Qiaofeng Tan. 2023-03-13. Mechanical-scan-free and multi-color super-resolution imaging with diffractive spot array illumination. https://arxiv.org/abs/2303.06988

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