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arXiv · 2304.08194

Strategies for deliveries of anti-cancer drugs from perspectives of a measurement theory and an adsorption theory

Ken-ichi Amano·Takumi Otake
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Abstract

In this letter, we present anti-cancer drug delivery strategies using knowledges obtained from our recent studies. We have conducted inverse analyses of "density distributions of colloidal particles near a focused surface" and "pair potentials between the surface and the colloidal particle" using data measured by optical tweezers (OT) and atomic force microscopy (AFM). Non-additive Asakura-Oosawa (NAO) theory and a lattice theory in statistical mechanics of simple polymers have been also our research topics. Summarizing the knowledges, we propose two strategies to increase the delivery rate of capsule shaped anti-cancer drugs to cancer cells. We consider that enhanced repulsion between the normal cell and the drug accelerates the attraction between the cancer cell and the drug, which can be named enhanced repulsion and accelerated adsorption (ERAA) effect. To realize the ERAA effect, we propose a supporting method for measuring the interactions using OT and AFM. In the second strategy, dose of water-soluble polymers is considered to realize adsorptions of the drugs and cancer cell derived exosomes onto the cancer cells, which we call non-specific and selective adsorption (NSSA) effect. In the main text, we explain the NSSA effect using the NAO theory. Moreover, we explain that structural stabilities of normal dispersed proteins around the cancer cells are not largely destroyed by the dosed polymers from the viewpoint of the lattice theory.

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Ken-ichi Amano, Takumi Otake. 2023-04-17. Strategies for deliveries of anti-cancer drugs from perspectives of a measurement theory and an adsorption theory. https://arxiv.org/abs/2304.08194

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