Synthesis of Annotated Colorectal Cancer Tissue Images from Gland Layout

Srijay Deshpande; Fayyaz Minhas; Nasir Rajpoot

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arXiv · 2305.05006

Synthesis of Annotated Colorectal Cancer Tissue Images from Gland Layout

Srijay Deshpande·Fayyaz Minhas·Nasir Rajpoot

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Abstract

Generating realistic tissue images with annotations is a challenging task that is important in many computational histopathology applications. Synthetically generated images and annotations are valuable for training and evaluating algorithms in this domain. To address this, we propose an interactive framework generating pairs of realistic colorectal cancer histology images with corresponding glandular masks from glandular structure layouts. The framework accurately captures vital features like stroma, goblet cells, and glandular lumen. Users can control gland appearance by adjusting parameters such as the number of glands, their locations, and sizes. The generated images exhibit good Frechet Inception Distance (FID) scores compared to the state-of-the-art image-to-image translation model. Additionally, we demonstrate the utility of our synthetic annotations for evaluating gland segmentation algorithms. Furthermore, we present a methodology for constructing glandular masks using advanced deep generative models, such as latent diffusion models. These masks enable tissue image generation through a residual encoder-decoder network.

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BibTeX RIS

Srijay Deshpande, Fayyaz Minhas, Nasir Rajpoot. 2023-05-08. Synthesis of Annotated Colorectal Cancer Tissue Images from Gland Layout. https://arxiv.org/abs/2305.05006

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