Topological Data Analysis Assisted Automated Sleep Stage Scoring Using Airflow Signals

Abstract

Objective: Breathing pattern variability (BPV), as a universal physiological feature, encodes rich health information. We aim to show that, a high-quality automatic sleep stage scoring based on a proper quantification of BPV extracting from the single airflow signal can be achieved. Methods: Topological data analysis (TDA) is applied to characterize BPV from the intrinsically nonstationary airflow signal, where the extracted features are used to train an automatic sleep stage scoring model using the XGBoost learner. The noise and artifacts commonly present in the airflow signal are recycled to enhance the performance of the trained system. The state-of-the-art approach is implemented for a comparison. Results: When applied to 30 whole night polysomnogram signals with standard annotations, the leave-one-subject-out cross-validation shows that the proposed features (overall accuracy 78.8\%$\pm$8.7\% and Cohen's kappa 0.56$\pm 0.15$) outperforms those considered in the state-of-the-art work (overall accuracy 75.0\%$\pm$9.6\% and Cohen's kappa 0.50$\pm 0.15$) when applied to automatically score wake, rapid eyeball movement (REM) and non-REM (NREM). The TDA features are shown to contain complementary information to the traditional features commonly used in the literature via examining the feature importance. The respiratory quality index is found to be essential in the trained system. Conclusion: The proposed TDA-assisted automatic annotation system can accurately distinguish wake, REM and NREM from the airflow signal. Significance: Since only one single airflow channel is needed and BPV is universal, the result suggests that the TDA-assisted signal processing has potential to be applied to other biomedical signals and homecare problems other than the sleep stage annotation.