Searcharxiv⌕ Search
Home/Archive/arXiv

arXiv · 2306.14860

Nanoextraction from a flow of a highly diluted solution for much-improved sensitivity in offline chemical detection and quantification

Hongyan Wu·Quynh Nhu Le·Binglin Zeng·Xuehua Zhang
View original source ↗Read source document ↗Export metadata ↓

Abstract

Preconcentration of the target compound is a critical step that ensures the accuracy of the subsequent chemical analysis. In this work, we present a straightforward yet effective liquid-liquid extraction approach based on surface nanodroplets (i.e., nanoextraction) for offline analysis of highly diluted sample solutions. The extraction and sample collection were streamlined in a 3-m microcapillary tube. The concentration of the target analyte in surface nanodroplets was significantly increased compared to the concentration in the sample solution, reaching several orders of magnitudes. A limit of detection (LOD) was decreased by a factor of $\sim 10^3$ for an organic model compound in Fourier-transform infrared spectroscopy (FTIR) measurements and $\sim 10^5$ for a model fluorescent dye in fluorescence detection. The quantitative analysis of the organic compound was also achieved in a wide concentration region from $10^{-3}$ M to $10^{-4}$ M. The total volume of surface nanodroplets can be manipulated to further enhance extraction efficiency, according to the principle that governs droplet formation by solvent exchange. Additionally, our method exhibited significantly improved sensitivity compared to traditional dispersive liquid-liquid microextraction (DLLME). The LOD of the fluorescent dye and the organic model compound obtained with DLLME was 3 orders of magnitude and 20 times higher than the LOD achieved through nanoextraction approach. The nanoextraction developed in this work can be applied to preconcentrate multi-compounds from river water samples, without clear interference from each other. This can further extend its applicability for the detection and quantification of target analytes in complex aqueous samples by common analytical instruments.

Explore related subjects

physics.chem-ph

Keep this discovery

BibTeXRIS

Hongyan Wu, Quynh Nhu Le, Binglin Zeng, Xuehua Zhang. 2023-06-26. Nanoextraction from a flow of a highly diluted solution for much-improved sensitivity in offline chemical detection and quantification. https://arxiv.org/abs/2306.14860

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related papers

arXiv2026

Breaking Water at Graphene Defects

Water dissociation at solid surfaces underpins processes ranging from corrosion and catalysis to electrochemistry and photovoltaics. Defects often serve as reactive sites for dissociation, yet how solvation influences water dissociation at such sites remains poorly understood. Here, we use state-of-the-art machine-learned interatomic potentials to explore water dissociation at defective graphene-water interfaces. We show that solvation qualitatively changes the reaction mechanism at a graphene single vacancy (SV), opening pathways that are absent for an isolated water molecule. Whereas the gas-phase process proceeds via a single concerted channel, the solvated SV splits water through two competing pathways: a basic route forming SV-H and OH-(aq), and an acidic route forming SV-OH and H3O+(aq). These lower-barrier pathways produce distinct chemisorbed intermediates that enhance graphene-water adsorption. Accordingly, even a simple carbon vacancy gives rise to unexpectedly rich interfacial chemistry, coupling surface chemistry to interfacial charge and wettability, with implications for carbon functionalization and nanofluidic transport.

physics.chem-ph↗
arXiv2026

Comprehensive Study of L-Menthol and Octanoic Acid as a Hydrophobic Eutectic Solvent

Hydrophobic eutectic solvents (HES) based on natural compounds represent promising green alternatives to conventional solvents. In this work, we investigate the physicochemical, structural, and dynamical properties of an ES formed by L-menthol and octanoic acid using a combined experimental and molecular dynamics simulation approach. Five compositions with molar ratios from 1:3 to 3:1 were studied with molecular dynamics simulation in the temperature range 15 degrees C to 35 degrees C. Experimental measurements of density and viscosity in the temperature range from 5 degrees C to 35 degrees C were complemented with results obtained from MD simulations employing the OPLS force field. Structural analyses based on radial distribution functions and Kirkwood-Buff integrals reveal that the dominant interactions in the mixture are hydrogen bonds between L-menthol and octanoic acid molecules. Dynamic properties, including self-diffusion coefficients and hydrogen-bond lifetimes, indicate that intermolecular hydrogen bonds between the two components are stronger and longer-lived than bonds between identical species. These findings provide molecular-level insight into the structure and transport properties of menthol-based ESs relevant for green solvent applications.

physics.chem-ph↗
arXiv2026

More is not always better: Dissociative photoionization limits the EUV absorbing photacid generator pentafluorophenyl triflate in photolithography

Pentafluorophenyl triflate has been explored as a highly absorbing neutral photoacid generator (PAG) candidate for next generation chemically amplified resists used in extreme ultraviolet (EUV) lithography. Although increased fluorination enhances EUV absorption, this study demonstrates that such an approach does not necessarily improve photoacid generation efficiency. Using photoelectron-photoion coincidence (PEPICO) spectroscopy at the 92 eV photon energy of the EUV scanners in combination with quantum chemical calculations, the dissociative photoionization of pentafluorophenyl triflate was systematically investigated. The photoionization mass spectrum reveals extensive fragmentation, with the parent ion contributing only 3.1 % of the total signal and CF$_3^+$ representing the dominant product ion. Computed appearance energies align well with experimental trends and support a sequential fragmentation pathway involving loss of SO$_2$, CF$_3$, and CO. Crucially, none of the major dissociation channels yield precursors capable of forming triflic acid, the strong photoacid required for efficient deprotection reactions in chemically amplified resists. Combined with previous dissociative electron attachment studies indicating similarly unfavorable fragmentation, the results demonstrate that despite its high EUV absorption cross section, pentafluorophenyl triflate is unsuitable as a PAG for EUV lithography. The findings highlight the importance of understanding fundamental photoionization and electron interaction mechanisms to guide the rational design of next generation high performance EUV photoresists.

physics.chem-ph↗