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arXiv · 2307.00904

An open-source deep learning algorithm for efficient and fully-automatic analysis of the choroid in optical coherence tomography

Jamie Burke·Justin Engelmann·Charlene Hamid·Megan Reid-Schachter·Tom Pearson·Dan Pugh·Neeraj Dhaun·Stuart King·Tom MacGillivray·Miguel O. Bernabeu·Amos Storkey·Ian J. C. MacCormick
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Abstract

Purpose: To develop an open-source, fully-automatic deep learning algorithm, DeepGPET, for choroid region segmentation in optical coherence tomography (OCT) data. Methods: We used a dataset of 715 OCT B-scans (82 subjects, 115 eyes) from 3 clinical studies related to systemic disease. Ground truth segmentations were generated using a clinically validated, semi-automatic choroid segmentation method, Gaussian Process Edge Tracing (GPET). We finetuned a UNet with MobileNetV3 backbone pre-trained on ImageNet. Standard segmentation agreement metrics, as well as derived measures of choroidal thickness and area, were used to evaluate DeepGPET, alongside qualitative evaluation from a clinical ophthalmologist. Results: DeepGPET achieves excellent agreement with GPET on data from 3 clinical studies (AUC=0.9994, Dice=0.9664; Pearson correlation of 0.8908 for choroidal thickness and 0.9082 for choroidal area), while reducing the mean processing time per image on a standard laptop CPU from 34.49s ($\pm$15.09) using GPET to 1.25s ($\pm$0.10) using DeepGPET. Both methods performed similarly according to a clinical ophthalmologist, who qualitatively judged a subset of segmentations by GPET and DeepGPET, based on smoothness and accuracy of segmentations. Conclusions: DeepGPET, a fully-automatic, open-source algorithm for choroidal segmentation, will enable researchers to efficiently extract choroidal measurements, even for large datasets. As no manual interventions are required, DeepGPET is less subjective than semi-automatic methods and could be deployed in clinical practice without necessitating a trained operator.

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Jamie Burke, Justin Engelmann, Charlene Hamid, Megan Reid-Schachter, Tom Pearson, Dan Pugh, Neeraj Dhaun, Stuart King, Tom MacGillivray, Miguel O. Bernabeu, Amos Storkey, Ian J. C. MacCormick. 2023-07-03. An open-source deep learning algorithm for efficient and fully-automatic analysis of the choroid in optical coherence tomography. https://arxiv.org/abs/2307.00904

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