Noise in the direction of motion determines the spatial distribution and proliferation of migrating cell collectives

Abstract

A variety of living and non-living systems exhibit collective motion. From swarm robotics to bacterial swarms, and tissue wound healing to human crowds, examples of collective motion are highly diverse but all of them share the common necessary ingredient of moving and interacting agents. While collective motion has been extensively studied in non-proliferating systems, how the proliferation of constituent agents affects their collective behavior is not well understood. Here, we focus on growing active agents as a model for cells and study how the interplay between noise in their direction of movement and proliferation determines the overall spatial pattern of collective motion. In this agent-based model, motile cells possess the ability to adhere to each other through cell-cell adhesion, grow in size and divide. Cell-cell interactions influence not only the direction of cell movement but also cell growth through a force-dependent mechanical feedback process. We show that noise in the direction of a cell's motion has striking effects on the emergent spatial distribution of cell collectives and proliferation. While higher noise strength leads to a random spatial distribution of cells, we also observe increased cell proliferation. On the other hand, low noise strength leads to a ring-like spatial distribution of cell collectives together with lower proliferation. Our findings provide insight into how noise in the direction of cell motion determines the local spatial organization of cells with consequent mechanical feedback on cell division impacting cell proliferation due to the formation of cell clusters.