Understanding AKT-mediated chemoresistance: the relationship between ion channels and AKT activation

Rédoane Daoudi

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arXiv · 2307.07427

Understanding AKT-mediated chemoresistance: the relationship between ion channels and AKT activation

Rédoane Daoudi

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Abstract

Overcoming chemoresistance is a challenge for multiple chemotherapeutics agents like cisplatin. ABC transporters such as MDR1 or MRPs and PI3K/AKT pathway have been proposed as actors of chemoresistance in several cancers. In this review we describe two downstream targets of Akt: c-myc and p53 in the chemoresistance. We suggest a potential link between p53, c-myc and ABC transporters expression. Consequently a link between Akt and ABC transporters-mediated chemoresistance may exist. Finally we show that Akt activation may be Orai-dependent and/or TRPC-dependent, suggesting that these ion channels could constitute a therapeutic target in cancer.

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Rédoane Daoudi. 2023-07-13. Understanding AKT-mediated chemoresistance: the relationship between ion channels and AKT activation. https://arxiv.org/abs/2307.07427

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