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arXiv · 2308.03714

The role of APOBEC3-induced mutations in the differential evolution of monkeypox virus

Xiangting Li·Sara Habibipour·Tom Chou·Otto O. Yang
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Abstract

Recent studies show that newly sampled monkeypox virus (MPXV) genomes exhibit mutations consistent with Apolipoprotein B mRNA Editing Catalytic Polypeptide-like3 (APOBEC3)-mediated editing, compared to MPXV genomes collected earlier. It is unclear whether these single nucleotide polymorphisms (SNPs) result from APOBEC3-induced editing or are a consequence of genetic drift within one or more MPXV animal reservoirs. We develop a simple method based on a generalization of the General-Time-Reversible (GTR) model to show that the observed SNPs are likely the result of APOBEC3-induced editing. The statistical features allow us to extract lineage information and estimate evolutionary events.

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Xiangting Li, Sara Habibipour, Tom Chou, Otto O. Yang. 2023-08-07. The role of APOBEC3-induced mutations in the differential evolution of monkeypox virus. https://doi.org/10.1093/ve%2Fvead058

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