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arXiv · 2310.19685

DGFN: Double Generative Flow Networks

Elaine Lau·Nikhil Vemgal·Doina Precup·Emmanuel Bengio
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Abstract

Deep learning is emerging as an effective tool in drug discovery, with potential applications in both predictive and generative models. Generative Flow Networks (GFlowNets/GFNs) are a recently introduced method recognized for the ability to generate diverse candidates, in particular in small molecule generation tasks. In this work, we introduce double GFlowNets (DGFNs). Drawing inspiration from reinforcement learning and Double Deep Q-Learning, we introduce a target network used to sample trajectories, while updating the main network with these sampled trajectories. Empirical results confirm that DGFNs effectively enhance exploration in sparse reward domains and high-dimensional state spaces, both challenging aspects of de-novo design in drug discovery.

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Elaine Lau, Nikhil Vemgal, Doina Precup, Emmanuel Bengio. 2023-10-30. DGFN: Double Generative Flow Networks. https://arxiv.org/abs/2310.19685

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