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arXiv · 2311.01480

Tests for strict monotonic trend in bio-medical dose-response relationships (respective concentration-response or exposure-response relationships) -- a biostatistical perspective

Ludwig A. Hothorn
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Abstract

Evidence of a global trend in dose-response dependencies is commonly used in bio-medicine and epidemiology, especially because this represents a causality criterion. However, conventional trend tests indicate a significant trend even when dependence is in the opposite direction for low doses when the high dose alone has a superior effect. Here we present a trend test for a strictly monotonic increasing (or decreasing) trend, evaluate selected sample data for it, and provide corresponding R code using CRAN packages.

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Ludwig A. Hothorn. 2023-11-02. Tests for strict monotonic trend in bio-medical dose-response relationships (respective concentration-response or exposure-response relationships) -- a biostatistical perspective. https://arxiv.org/abs/2311.01480

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