SearcharxivSearch

arXiv · 2312.02513

Asymptotic Theory of the Best-Choice Rerandomization using the Mahalanobis Distance

Abstract

Rerandomization, a design that utilizes pretreatment covariates and improves their balance between different treatment groups, has received attention recently in both theory and practice. From a survey by Bruhn and McKenzie (2009), there are at least two types of rerandomization that are used in practice: the first rerandomizes the treatment assignment until covariate imbalance is below a prespecified threshold; the second randomizes the treatment assignment multiple times and chooses the one with the best covariate balance. In this paper we will consider the second type of rerandomization, namely the best-choice rerandomization, whose theory and inference are still lacking in the literature. In particular, we will focus on the best-choice rerandomization that uses the Mahalanobis distance to measure covariate imbalance, which is one of the most commonly used imbalance measure for multivariate covariates and is invariant to affine transformations of covariates. We will study the large-sample repeatedly sampling properties of the best-choice rerandomization, allowing both the number of covariates and the number of tried complete randomizations to increase with the sample size. We show that the asymptotic distribution of the difference-in-means estimator is more concentrated around the true average treatment effect under rerandomization than under the complete randomization, and propose large-sample accurate confidence intervals for rerandomization that are shorter than that for the completely randomized experiment. We further demonstrate that, with moderate number of covariates and with the number of tried randomizations increasing polynomially with the sample size, the best-choice rerandomization can achieve the ideally optimal precision that one can expect even with perfectly balanced covariates. The developed theory and methods are also illustrated using real field experiments.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Yuhao Wang, Xinran Li. 2023-12-05. Asymptotic Theory of the Best-Choice Rerandomization using the Mahalanobis Distance. https://arxiv.org/abs/2312.02513

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related papers

Surprise Reduction and Nullification in Bayesian and Inverse Bayesian Inference under Ambiguous Prediction-Error Attribution

In non-stationary environments, prediction errors may signal environmental change or transient outliers, and adaptive systems must track such changes without overreacting to outliers. We distinguish surprise reduction, which updates beliefs to fit observations, from surprise nullification, which weakens constraints imposed by the predictive structure, and formalize both within Bayesian and inverse Bayesian (BIB) inference. Belief and likelihood updates are derived from variational objectives sharing a nullification strength, determined endogenously by minimizing surprise under the candidate post-update predictive distribution. In the Gaussian case, nullification expands belief and likelihood variances by a common factor relative to standard Bayesian updating, leaving the ratio unchanged. BIB thus defers attribution of the prediction error, committing to neither latent-state change nor observation-process uncertainty. The nullification strength is carried over as a candidate and is maintained or released according to the predictive surprise of the next observation. In a mean estimation task with outliers and changepoints, no scanned parameter setting of a Sage-Husa-type adaptive Kalman filter, fixed-strength BIB variant, or belief-forgetting-only variant outperforms BIB in both changepoint tracking and post-outlier stability. An oracle-informed reduced Bayesian model tracks changepoints better but is less stable after outliers. Although BIB maintains no explicit hypotheses about changepoints or outliers, it generates event-dependent dynamics. The learning rate increases after changepoints, whereas after outliers, nullification is released, and this increase is suppressed. Deferring attribution and letting subsequent observations differentiate the responses may constitute a principle of adaptive inference in non-stationary environments.

stat.ME

Generalized Ridge Refitting for the Lasso and Prediction Improvement Bounds

We study a class of Lasso based estimators obtained by applying a quadratic correction on the Lasso equicorrelation set. The penalty matrix determines both the magnitude and geometry of the correction and contains, among other cases, the isotropic Lasso--Ridge correction, least squares refitting, Gram proportional interpolation between the Lasso and least squares, and coordinate specific penalties. We first derive a closed form representation and isolate the positive gain component of the resulting prediction improvement. We then control the remaining stochastic linear term in expectation by localizing the random signed equicorrelation model around a deterministic reference support. This yields a finite sample expectation bound that explicitly accounts for the randomness induced by Lasso model selection. The resulting decomposition provides a unified framework for understanding when Lasso based quadratic corrections can improve prediction.

stat.ME

Discretization in covariate-adaptive randomization: gains and losses

Covariate-adaptive randomization(CAR) is widely implemented in clinical trials to balance prognostic covariates across treatment arms. Continuous covariates are often discretized into strata in practice, yet their consequences are not clearly understood. This paper provides a comprehensive study of the impact of discretization on both the CAR design process and the inferential results thereafter. We establish the asymptotic properties of both imbalance measures and treatment effect estimators under discretized and non-discretized settings. Practical recommendations are given on when and how discretization should be employed. We show that discretization in design is generally recommended, as it enhances robustness against model misspecification. However, if the true model is known, the most efficient strategy is to balance covariates according to that model in the design. The theoretical results are corroborated by extensive simulation studies and an empirical application to a diabetes trial dataset. Together, the results clarify the gains and losses of discretization in CAR and pave the way for learning impact of discretization to other designs and beyond.

stat.ME