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arXiv · 2312.02922

Quaternion-Aligned Electroanatomical Models of the Murine Atria from Standard-Output Functional and Structural Imaging

Gavin Tumlinson·Enaam Chleilat·Josef Madl·Peter Kohl·Viviane Timmermann
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Abstract

Our evolving understanding of the heterocellular cardiac environment demands innovative tools for its study. While murine models are lauded for their versatility and accessibility, they are constrained by scale; tools designed for larger subjects are unsuitable in mice. Advanced techniques, such as optical trans-membrane potential mapping and three-dimensional microscopy may fill this void. To enhance the utility of these methods, we developed a novel cross-correlation technique grounded in quaternion mathematics. The successful integration of multimodal observations represents a significant advancement in our ability to study cardiac electrophysiology in murine models, providing insight into mechanisms previously unexplored due to technical constraints.

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Gavin Tumlinson, Enaam Chleilat, Josef Madl, Peter Kohl, Viviane Timmermann. 2023-12-05. Quaternion-Aligned Electroanatomical Models of the Murine Atria from Standard-Output Functional and Structural Imaging. https://arxiv.org/abs/2312.02922

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