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arXiv · 2401.01438

Live-cell imaging powered by computation

Hari Shroff·Ilaria Testa·Florian Jug·Suliana Manley
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Abstract

The proliferation of microscopy methods for live-cell imaging offers many new possibilities for users but can also be challenging to navigate. We focus here on computational methods that promise to boost live-cell fluorescence microscopy, where intra-cellular dynamics and cell viability constrain measurements considerably. Considering the tradeoffs between signal-to-noise ratio (SNR), spatial resolution, temporal resolution, and multi-color and multi-channel capacity, we review computational methods that can be layered on top of commonly used existing microscopies, as well as hybrid methods that integrate computation and microscope hardware.

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Hari Shroff, Ilaria Testa, Florian Jug, Suliana Manley. 2024-01-02. Live-cell imaging powered by computation. https://arxiv.org/abs/2401.01438

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