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arXiv · 2401.06938

Dynamics and numerical simulations to predict empirical antibiotic treatment of multi-resistant Pseudomonas aeruginosa infection

Javier López-de-la-Cruz·María Pérez-Aranda·Ana Alcudia·Belén Begines·Tomás Caraballo·Eloísa Pajuelo·Pedro J. Ginel
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Abstract

This work discloses an epidemiological mathematical model to predict an empirical treatment for dogs infected by Pseudomonas aeruginosa. This dangerous pathogen is one of the leading causes of multi-resistant infections and can be transmitted from dogs to humans. Numerical simulations and appropriated codes were developed using Matlab software to gather information concerning long-time dynamics of the susceptible, infected and recovered individuals. All data compiled from the mathematical model was used to provide an appropriated antibiotic sensitivity panel for this specific infection. In this study, several variables have been included in this model to predict which treatment should be prescribed in emergency cases, when there is no time to perform an antibiogram or the cost of it could not be assumed. In particular, we highlight the use of this model aiming to become part of the convenient toolbox of Public Health research and decision-making in the design of the mitigation strategy of bacterial pathogens.

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Javier López-de-la-Cruz, María Pérez-Aranda, Ana Alcudia, Belén Begines, Tomás Caraballo, Eloísa Pajuelo, Pedro J. Ginel. 2024-01-13. Dynamics and numerical simulations to predict empirical antibiotic treatment of multi-resistant Pseudomonas aeruginosa infection. https://doi.org/10.1016/j.cnsns.2020.105418

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