Methylation Operation Wizard (MeOW): Identification of differentially methylated regions in long-read sequencing data

Miranda PG Zalusky; Danny E Miller

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arXiv · 2402.17182

Methylation Operation Wizard (MeOW): Identification of differentially methylated regions in long-read sequencing data

Miranda PG Zalusky·Danny E Miller

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Abstract

Long-read sequencing (LRS) is able to simultaneously capture information about both DNA sequence and modifications, such as CpG methylation in a single sequencing experiment. Here we present Methylation Operation Wizard (MeOW), a program to identify and prioritize differentially methylated regions (DMRs) genome-wide using LRS data. MeOW can be run using either a file containing counts of per-nucleotide methylated CpG sites or with a bam file containing modified base tags.

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Miranda PG Zalusky, Danny E Miller. 2024-02-27. Methylation Operation Wizard (MeOW): Identification of differentially methylated regions in long-read sequencing data. https://arxiv.org/abs/2402.17182

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