Multi-omics network reconstruction with collaborative graphical lasso

Abstract

Motivation: In recent years, the availability of multi-omics data has increased substantially. Multi-omics data integration methods mainly aim to leverage different molecular layers to gain a complete molecular description of biological processes. An attractive integration approach is the reconstruction of multi-omics networks. However, the development of effective multi-omics network reconstruction strategies lags behind. Results: In this study, we introduce collaborative graphical lasso, a novel approach that extends graphical lasso by incorporating collaboration between omics layers, thereby improving multi-omics data integration and enhancing network inference. Our method leverages a collaborative penalty term, which harmonizes the contribution of the omics layers to the reconstruction of the network structure. This promotes a cohesive integration of information across modalities, and it is introduced alongside a dual regularization scheme that separately controls sparsity within and between layers. To address the challenge of model selection in this framework, we propose XStARS, a stability-based criterion for multi-dimensional hyperparameter tuning. We assess the performance of collaborative graphical lasso and the corresponding model selection procedure through simulations, and we apply them to publicly available multi-omics data. This application demonstrated collaborative graphical lasso recovers established biological interactions while suggesting novel, biologically coherent connections. Availability and implementation: We implemented collaborative graphical lasso as an R package, available on CRAN as coglasso. The results of the manuscript can be reproduced running the code available at https://github.com/DrQuestion/coglasso_reproducible_code