Emergent Language Symbolic Autoencoder (ELSA) with Weak Supervision to Model Hierarchical Brain Networks

Abstract

Brain networks display a hierarchical organization, a complexity that poses a challenge for existing deep learning models, often structured as flat classifiers, leading to difficulties in interpretability and the 'black box' issue. To bridge this gap, we propose a novel architecture: a symbolic autoencoder informed by weak supervision and an Emergent Language (EL) framework. This model moves beyond traditional flat classifiers by producing hierarchical clusters and corresponding imagery, subsequently represented through symbolic sentences to improve the clinical interpretability of hierarchically organized data such as intrinsic brain networks, which can be characterized using resting-state fMRI images. Our innovation includes a generalized hierarchical loss function designed to ensure that both sentences and images accurately reflect the hierarchical structure of functional brain networks. This enables us to model functional brain networks from a broader perspective down to more granular details. Furthermore, we introduce a quantitative method to assess the hierarchical consistency of these symbolic representations. Our qualitative analyses show that our model successfully generates hierarchically organized, clinically interpretable images, a finding supported by our quantitative evaluations. We find that our best performing loss function leads to a hierarchical consistency of over 97% when identifying images corresponding to brain networks. This approach not only advances the interpretability of deep learning models in neuroimaging analysis but also represents a significant step towards modeling the intricate hierarchical nature of brain networks.