Alpha rhythm slowing in temporal epilepsy across Scalp EEG and MEG

Vytene Janiukstyte; Csaba Kozma; Thomas W. Owen; Umair J Chaudhury; Beate Diehl; Louis Lemieux; John S Duncan; Fergus Rugg-Gunn; Jane de Tisi; Yujiang Wang; Peter N. Taylor

arXiv · 2404.10869

Alpha rhythm slowing in temporal epilepsy across Scalp EEG and MEG

Vytene Janiukstyte·Csaba Kozma·Thomas W. Owen·Umair J Chaudhury·Beate Diehl·Louis Lemieux·John S Duncan·Fergus Rugg-Gunn·Jane de Tisi·Yujiang Wang·Peter N. Taylor

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Abstract

EEG slowing is reported in various neurological disorders including Alzheimer's, Parkinson's and Epilepsy. Here, we investigate alpha rhythm slowing in individuals with refractory temporal lobe epilepsy (TLE), compared to healthy controls, using scalp electroencephalography (EEG) and magnetoencephalography (MEG). We retrospectively analysed data from 17,(46) healthy controls and 22,(24) individuals with TLE who underwent scalp EEG and (MEG) recordings as part of presurgical evaluation. Resting-state, eyes-closed recordings were source reconstructed using the standardized low-resolution brain electrographic tomography (sLORETA) method. We extracted low (slow) 6-9 Hz and high (fast) 10-11 Hz alpha relative band power and calculated the alpha power ratio by dividing low (slow) alpha by high (fast) alpha. This ratio was computed for all brain regions in all individuals. Alpha oscillations were slower in individuals with TLE than controls (p<0.05). This effect was present in both the ipsilateral and contralateral hemispheres, and across widespread brain regions. Alpha slowing in TLE was found in both EEG and MEG recordings. We interpret greater low (slow)-alpha as greater deviation from health.

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Vytene Janiukstyte, Csaba Kozma, Thomas W. Owen, Umair J Chaudhury, Beate Diehl, Louis Lemieux, John S Duncan, Fergus Rugg-Gunn, Jane de Tisi, Yujiang Wang, Peter N. Taylor. 2024-04-16. Alpha rhythm slowing in temporal epilepsy across Scalp EEG and MEG. https://arxiv.org/abs/2404.10869

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