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arXiv · 2404.13113

Towards quantum computing for clinical trial design and optimization: A perspective on new opportunities and challenges

Hakan Doga·M. Emre Sahin·Joao Bettencourt-Silva·Anh Pham·Eunyoung Kim·Alan Andress·Sudhir Saxena·Aritra Bose·Laxmi Parida·Jan Lukas Robertus·Hideaki Kawaguchi·Radwa Soliman·Daniel Blankenberg
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Abstract

Clinical trials are pivotal in the drug discovery process to determine the safety and efficacy of a drug candidate. The high failure rates of these trials are attributed to deficiencies in clinical model development and protocol design. Improvements in the clinical drug design process could therefore yield significant benefits for all stakeholders involved. This paper examines the current challenges faced in clinical trial design and optimization, reviews established classical computational approaches, and introduces quantum algorithms aimed at enhancing these processes. Specifically, the focus is on three critical aspects: clinical trial simulations, site selection, and cohort identification. This study aims to provide a comprehensive framework that leverages quantum computing to innovate and refine the efficiency and effectiveness of clinical trials.

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Hakan Doga, M. Emre Sahin, Joao Bettencourt-Silva, Anh Pham, Eunyoung Kim, Alan Andress, Sudhir Saxena, Aritra Bose, Laxmi Parida, Jan Lukas Robertus, Hideaki Kawaguchi, Radwa Soliman, Daniel Blankenberg. 2024-04-19. Towards quantum computing for clinical trial design and optimization: A perspective on new opportunities and challenges. https://doi.org/10.1016/j.tips.2024.08.005

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