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arXiv · 2404.14224

Modeling principles for a physiology-based whole-body model of human metabolism

Laura Hjort Blicher·Peter Emil Carstensen·Jacob Bendsen·Henrik Linden·Bjørn Hald·Kim Kristensen·John Bagterp Jørgensen
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Abstract

Physiological whole-body models are valuable tools for the development of novel drugs where understanding the system aspects is important. This paper presents a generalized model that encapsulates the structure and flow of whole-body human physiology. The model contains vascular, interstitial, and cellular subcompartments for each organ. Scaling of volumes and blood flows is described to allow for investigation across populations or specific patient groups. The model equations and the corresponding parameters are presented along with a catalog of functions that can be used to define the organ transport model and the biochemical reaction model. A simple example illustrates the procedure.

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Laura Hjort Blicher, Peter Emil Carstensen, Jacob Bendsen, Henrik Linden, Bjørn Hald, Kim Kristensen, John Bagterp Jørgensen. 2024-04-22. Modeling principles for a physiology-based whole-body model of human metabolism. https://arxiv.org/abs/2404.14224

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