Searcharxiv⌕ Search
Home/Archive/arXiv

arXiv · 2405.06403

Stochastic Mathematical Modelling Study for Understanding the Extinction, Persistence and Control of SARS-CoV-2 Virus at the Within-host Level

Bishal Chhetri·B. V. Ratish Kumar
View original source ↗Read source document ↗Export metadata ↓

Abstract

Stochastic differential equations characterized by uncertainty are effective in modelling virus dynamics and provide an alternative to traditional deterministic models. Epidemic models are inevitably subjected to the randomness within the system or the environmental noise. In this paper, we analyze the stochastic within host compartment model for SARS-CoV-2 virus and explore its dynamics. We first examine the existence and positivity of the solution of the model using Ito's formula and the establish the stochastic boundedness and permanence of the model. Exponential stability of the infection free equilibrium state is established. Numerical simulations are conducted to complement the theoretical results. Environmental noise is found to play a crucial role in the dynamics of the disease and can even lead to the extinction of the disease. The model is also extended to a stochastic optimal control problem and the effectiveness of control measures, such as antiviral drugs and immunomodulators is investigated.

Explore related subjects

math.DS

Keep this discovery

BibTeXRIS

Bishal Chhetri, B. V. Ratish Kumar. 2024-05-10. Stochastic Mathematical Modelling Study for Understanding the Extinction, Persistence and Control of SARS-CoV-2 Virus at the Within-host Level. https://arxiv.org/abs/2405.06403

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related papers

arXiv2026

Admissible Fourier Lengths, KAM Reducibility, and Spectral Applications

We develop a perturbative KAM reducibility theory for one-frequency $\mathrm{SL}(2,\mathbb{R})$ cocycles based on an admissible Fourier length $\ell$. The regularity relevant to the iteration is measured by positive adapted Fourier width rather than ordinary smoothness in the Euclidean length $|n|$. The same length governs Fourier decay, truncation and resonance scales, and the arithmetic condition controlling the small divisors. This framework contains the classical analytic and Gevrey settings, while non-monotone choices of $\ell$ allow classical nowhere differentiable Weierstrass-type perturbations and continuous perturbations outside every positive H\"older class. As spectral applications, we obtain purely absolutely continuous spectrum for every phase and $1/2$-H\"older continuity of the integrated density of states for the associated quasiperiodic Schr\"odinger operators. The Aubry dual has pure point spectrum for Lebesgue almost every dual phase, with eigenfunctions exponentially localized in the metric induced by $\ell$. We also construct nowhere differentiable quasiperiodic potentials with purely absolutely continuous Cantor spectrum.

math.DS↗
arXiv2026

Dynamics inside the attracting basins of some skew products

Polynomial skew products in $\mathbb{C}^2$ are maps of the form $F(z,w)=(P(z),Q(z,w))$, where $P$ and $Q$ are polynomials. Their local dynamics have been widely investigated. In this paper, we study the global dynamics inside Fatou components of some skew products. We consider all the inverse images in a Fatou component of a given point and use the Kobayashi metric to measure the distance between points. In the cases we consider, there are always arbitrarily large Kobayashi balls in the complement of these inverse sets.

math.DS↗
arXiv2026

Ergodicity of dynamical systems without uniqueness of orbits

Recently, there has been considerable interest in the study of non-deterministic dynamical systems. To analyze the chaotic behavior of such systems from a measure-theoretic viewpoint, it is desirable to consider ergodicity. However, the classical definition of ergodicity involves invariant sets, whose definition is not unique for non-deterministic dynamical systems. Thus, we are led to the question of which invariance yields an interesting definition of ergodicity. Here, we propose a definition based on the strong backward invariance and show that analogs of classical results hold. We also consider implications of the Birkhoff ergodic theorem for systems without uniqueness of orbits.

math.DS↗