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arXiv · 2405.14315

qtOCT: quantitative transmission optical coherence tomography

Wojciech Krauze·Martyna Mazur·Arkadiusz Kuś
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Abstract

Transmission optical coherence tomography (OCT) enables analysis of biological specimens in vitro through detection of forward scattered light. Up to now, transmission OCT was considered as a technique that cannot directly retrieve quantitative phase and is thus a qualitative method. In this paper, we present qtOCT, a novel quantitative transmission optical coherence tomography method. Unlike existing approaches, qtOCT allows for a direct, easy, fast and rigorous retrieval of 2D integrated phase information from transmission full-field swept-source OCT measurements. Our method is based on coherence gating and allows user-defined temporal measurement range selection, making it potentially suitable for analyzing multiple-scattering samples. We demonstrate high consistency between qtOCT and digital holographic microscopy phase images. This approach enhances transmission OCT capabilities, positioning it as a viable alternative to quantitative phase imaging techniques.

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Wojciech Krauze, Martyna Mazur, Arkadiusz Kuś. 2024-05-23. qtOCT: quantitative transmission optical coherence tomography. https://arxiv.org/abs/2405.14315

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