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arXiv · 2405.18329

Spatial-temporal analysis of neural desynchronization in sleep-like states reveals critical dynamics

Davor Curic·Surjeet Singh·Mojtaba Nazari·Majid H. Mohajerani·Joern Davidsen
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Abstract

Sleep is characterized by non-rapid eye movement (nREM) sleep, originating from widespread neuronal synchrony, and REM sleep, with neuronal desynchronization akin to waking behavior. While these were thought to be global brain states, recent research suggests otherwise. Using time-frequency analysis of mesoscopic voltage-sensitive dye recordings of mice in a urethane-anesthetized model of sleep, we find transient neural desynchronization occurring heterogeneously across the cortex within a background of synchronized neural activity, in a manner reminiscent of a critical spreading process and indicative of an "edge-of-synchronization phase" transition.

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Davor Curic, Surjeet Singh, Mojtaba Nazari, Majid H. Mohajerani, Joern Davidsen. 2024-05-28. Spatial-temporal analysis of neural desynchronization in sleep-like states reveals critical dynamics. https://doi.org/10.1103/physrevlett.132.218403

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