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arXiv · 2410.24122

Multiparameter optimal control of F1-ATPase

W. Callum Wareham·David A. Sivak
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Abstract

Biological molecular machines convert free energy between different forms in cells, often at high efficiency. Optimal control theory provides a framework to elucidate design principles governing energetically efficient driving. Here, we use linear-response theory to design efficient protocols exercising dynamic control of trap center and stiffness in a model of driven F1-ATPase. We find that the key design principles of an efficient protocol can be satisfied either by dynamic control of both parameters or by dynamic control of a single parameter and a good static choice for the second. These results illustrate that accessing a new degree of dynamic control provides varying performance improvements in different systems.

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W. Callum Wareham, David A. Sivak. 2024-10-31. Multiparameter optimal control of F1-ATPase. https://doi.org/10.1103/bm3d-c67v

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