Non-equilibrium phase transitions in hybrid Voronoi models of cell colonies

Mattia Miotto; Giancarlo Ruocco; Matteo Paoluzzi

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arXiv · 2411.08012

Non-equilibrium phase transitions in hybrid Voronoi models of cell colonies

Mattia Miotto·Giancarlo Ruocco·Matteo Paoluzzi

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Abstract

Eukaryotic cells are characterized by a stiff nucleus whose effect in modeling the collective behavior of cell aggregates is usually underestimated. However, increasing experimental evidence links nuclear modifications with phenotypic transition, like the one between epithelial and mesenchymal states. In this work, we explore the effect of short-range repulsive forces in the non-equilibrium dynamics of the self-propelled Voronoi model. We show that the competition between steric repulsions (representing nuclear/cellular compressibility) and Vertex interactions (mimicking cell-cell adhesion/interaction and cytoskeleton organization) generate a variety of non-equilibrium phase transitions from Motility-Induced Phase Separation to mesenchymal-like phases up to disordered confluent configurations. Notably, we found that tuning the nucleus's effective size/compressibility provides an additional way to cross the boundary between the different possible phases in line with experimental observations.

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Mattia Miotto, Giancarlo Ruocco, Matteo Paoluzzi. 2024-11-12. Non-equilibrium phase transitions in hybrid Voronoi models of cell colonies. https://arxiv.org/abs/2411.08012

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