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arXiv · 2412.06622

Generalized Design of Basket Trials with P-value Combination Test

Heng Zhou·Linda Sun·Fang Liu·Cong Chen
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Abstract

The oncology exploratory basket trial design with pruning and pooling (P&P) approach has gained increasing popularity in recent years for its simplicity and efficiency. This method was proposed based on binary endpoint, limiting its wider application. This short communication proposed a generalized framework of using P-value combination test to implement pruning and pooling process in basket trials. Only P-values of any type of statistical testing from each cohort are needed for decision making, which provides great flexibility for basket trial designs with P&P approach.

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Heng Zhou, Linda Sun, Fang Liu, Cong Chen. 2024-12-09. Generalized Design of Basket Trials with P-value Combination Test. https://arxiv.org/abs/2412.06622

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