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arXiv · 2412.16835

Quantum-inspired super-resolution of fluorescent point-like sources

Cheyenne S. Mitchell·Dhananjay Dhruva·Zachary P. Burke·David J. Durden·Armine I. Dingilian·Mikael P. Backlund
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Abstract

We report the experimental super-resolution of pairs of point-like fluorescent sources using a modified image inversion interferometer microscope. The technique is inspired by recent developments in the application of quantum parameter estimation theory to semiclassical imaging problems. We find that the image inversion technique requires special polarization filtering to account for the dipolar nature of the emission. Using an azimuthal polarizer, we obtain improvements in the Fisher information of point-source separation by over an order of magnitude relative to direct imaging. Unlike established super-resolution fluorescence techniques, the method does not require sequential photoswitching/blinking of the fluorophores, and thus could facilitate significant speed-ups for certain biological imaging/tracking tasks.

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Cheyenne S. Mitchell, Dhananjay Dhruva, Zachary P. Burke, David J. Durden, Armine I. Dingilian, Mikael P. Backlund. 2024-12-22. Quantum-inspired super-resolution of fluorescent point-like sources. https://doi.org/10.1038/s41467-026-72507-4

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