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arXiv · 2501.02176

Molecule-dynamic-based Aging Clock and Aging Roadmap Forecast with Sundial

Wei Wu·Zizhen Deng·Chi Zhang·Can Liao·Jinzhuo Wang
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Abstract

Addressing the unavoidable bias inherent in supervised aging clocks, we introduce Sundial, a novel framework that models molecular dynamics through a diffusion field, capturing both the population-level aging process and the individual-level relative aging order. Sundial enables unbiasedestimation of biological age and the forecast of aging roadmap. Fasteraging individuals from Sundial exhibit a higher disease risk compared to those identified from supervised aging clocks. This framework opens new avenues for exploring key topics, including age- and sex-specific aging dynamics and faster yet healthy aging paths.

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Wei Wu, Zizhen Deng, Chi Zhang, Can Liao, Jinzhuo Wang. 2025-01-04. Molecule-dynamic-based Aging Clock and Aging Roadmap Forecast with Sundial. https://arxiv.org/abs/2501.02176

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