Electrokinetic Flow Modeling Through Bone Scaffold

Mohammad Osaid; Debabrata Dasgupta

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arXiv · 2501.04025

Electrokinetic Flow Modeling Through Bone Scaffold

Mohammad Osaid·Debabrata Dasgupta

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Abstract

Fluid flow and mass transfer inside a bioreactor play a pivotal role in growing bone grafts, as cell proliferation is limited by the transport of nutrients and oxygen, as well as the removal of by-products from cells within the scaffold. Traditionally, perfusion bioreactors are used for tissue-engineered bone grafts. In this study, we modeled electrokinetic flow through the graft for tissue-engineered bone grafts and compared it to pressure-driven flows. The study highlights that electrokinetic transport offers several advantages over pressure-driven flow, such as improved oxygen transport and higher shear stress. Additionally, it provides generic benefits, including greater flexibility in control mechanisms, such as easier actuation and manipulation of flow.

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Mohammad Osaid, Debabrata Dasgupta. 2024-12-30. Electrokinetic Flow Modeling Through Bone Scaffold. https://arxiv.org/abs/2501.04025

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